I would say shoot the most gun you can shoot well with. If you handload, that gives a lot of flexibility and the ability to tune a load to the gun. I would also consider range. How far are typical shots? How far do you feel comfortable shooting? As someone from the east coast, most shots there are under 100 yards, but still, I shot a mulie in in NW CO at 260, which isn't far there. 260 is a long shot in woods country. I would limit myself to 400 with my 30-06 (Mauser), but that's me. For shorter range stuff, I like my 444 a lot better. It shoots subMOA for 5 shots at 100 yards and works well when it connects. If I was getting something new, I think the 7mm PRC would be hard to beat for all around. If I wanted stomp, I'd look at the 375 RCM.